Neonatal cholestasis occurs when bile does not flow properly from the liver to the intestine in a newborn. It can range from a mild condition that gets better without treatment to a more serious condition that can cause further health problems and liver disease.

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What are the signs and symptoms of neonatal cholestasis?

The symptoms of neonatal cholestasis may start to appear a few weeks after your baby’s birth. They can include:

  • A yellowing of the skin and whites of eyes (jaundice)
  • Dark colored urine
  • Not gaining weight
  • Itchy skin

What causes neonatal cholestasis?

Neonatal cholestasis can have a few different causes. These include:

  • Viruses
  • Liver diseases
  • Genetic disorders

How is neonatal cholestasis treated?

There is no specific treatment for neonatal cholestasis. Treatment is usually focused on managing specific symptoms. Some babies may need to take supplements or special formulas to help them absorb nutrients.

In rare cases, babies who develop end-stage liver disease may need liver transplantation surgery. Our experienced team at Connecticut Children’s will work with your family to discuss your child’s treatment options.